慢性乙型肝炎患者病理特征和临床客观生化指标特点及其相关性分析

摘要

Objective:To explore the correlation between clinical objective biochemical indexes and liver tissue pathology chronic hepatitis B( CHB) . Methods:The clinical data of liver tissue pathology and objective biochemical indexes in 468 CHB were collected from 2013 to 2015,the correlation of which were analyzed. Results:The inflammatory activity included G2 stage(70. 1%,maxium),G4 stage (1. 9%) and G0 stage(0. 0%,minimum). Fibrosis stage included S2 stage(40. 6%,maxium),S0 stage(9. 0%) and S4 stage (4. 3%,minimum). The inflammatory activity in different age patients was positively correlated with the fibrosis stage(P0. 05),and positively correlated with fibrosis stage(P0.05),与纤维化分期呈正相关关系(P<0.05).不同HBsAg水平和不同HBeAg水平与病理炎症活动度和纤维化分期均呈负相关关系(P<0.05).不同炎症活动度患者的丙氨酸氨基转移酶(AST)、白蛋白(ALB)、谷氨酰氨基转移酶(GGT)、凝血酶原时间(PT)间和不同纤维化分期患者的AST和GGT间差异均有统计学意义(P<0.05).结论:CHB患者的临床客观指标与肝脏组织病理有一定的相关性,患者的临床客观指标在一定程度上反映了肝脏的功能和患者的病情,有助于了解不能行肝组织活检患者的病情和抗病毒治疗的选择.