GPR30、ERα与cyclin D1在甲状腺乳头状癌组织中的表达

摘要

目的:探讨 G蛋白偶联受体30(GPR30)、雌激素受体(ER)α与细胞周期蛋白D1(cyclin D1)在甲状腺乳头状癌(PTC)组织中的表达.方法:收集76例PTC病人术后石蜡病理标本,采用免疫组织化学S-P染色法检测PTC中GPR30、ERα、cyclin D1的表达水平,分析其阳性表达率相互之间的差异及其与病人临床资料及病理特征的关系.结果:GRP30、ERα、cyclin D1阳性表达率分别为67.1%、76.3%、78.9%,癌旁正常组织未见表达.有淋巴结转移病人GRP30、cyclinD 1表达率均高于无转移者(P0.05).ERα表达率女性病人高于男性(P0.05).PTC中GPR30、ERα、cyclin D1两两之间表达均呈正相关关系(P0.05).The expressions of GPR30,ERα and cyclin D1 between any two in PTC tissues was positively correlated(P<0.01).Conclusions:The GPR30 and ERα combined with estrogen can affect the occurrence and development of PTC,which can be set as the potential targets of clinical diagnosis and treatment.