血清glactin-3、HMGB-1和TSGF联合检测在甲状腺癌诊断中的价值

摘要

目的:探讨血清半乳糖血凝素-3(glactin-3)、高迁移率族蛋白(HMGB-1)和肿瘤特异性生长因子(TSGF)联合检测在甲状腺癌诊断中的价值.方法:选取甲状腺癌病人60例、甲状腺腺瘤病人60例作为研究对象,另选取同期甲状腺组织正常的健康体检者60名作为对照组.采用 ELISA 法检测3组血清中glactin-3、HMGB-1和TSGF水平,比较三项指标单独检测和联合检测对甲状腺癌的诊断率.结果:甲状腺癌组病人血清glactin-3、HMGB-1和TSGF水平均明显高于甲状腺腺瘤组和对照组(P<0.01),而甲状腺腺瘤组三项指标水平亦均明显高于对照组(P<0.01).甲状腺癌组glactin-3、HMGB-1和TSGF检测阳性率均明显高于甲状腺腺瘤组(P<0.01),甲状腺癌组三项指标联合检测阳性率亦明显高于甲状腺腺瘤组(P<0.01).与单项检测相比,血清glactin-3、HMGB-1和TSGF联合检测诊断甲状腺癌效果最佳,其受试者工作特征曲线下面积和灵敏度、特异度分别为0.86和93.3%、91.7%.结论:血清glactin-3、HMGB-1和TSGF联合检测对甲状腺癌诊断率较高,敏感性较好.%Objective:To study the value of serum glactin-3,HMGB-1 and TSGF in the diagnosis of thyroid carcinoma.Methods:A total of 60 patients with thyroid carcinoma and 60 patients with thyroid adenoma were selected as the subjects,and the healthy subjects were selected as normal control group(n=60).The levels of serum glactin-3,HMGB-1 and TSGF were detected by enzyme-linked immunosorbent assay (ELISA).The levels of serum glactin-3,HMGB-1 and TSGF in thyroid carcinoma,thyroid adenoma and normal thyroid group were compared.The sensitivity and specificity of thyroid carcinoma between the three indexes were compared with the combined detection of thyroid carcinoma.Results:The levels of glactin-3,HMGB-1 and TSGF in thyroid cancer group were significantly higher than those in thyroid adenoma group(P<0.01),while those in thyroid adenoma group were significantly higher than those in control group(P <0.01).The positive rates and joint positive rates of glactin-3,HMGB-1 and TSGF in thyroid cancer group were significantly higher than those in thyroid adenoma group(P<0.01).The AUC,sensitivity and specificity of the three markers in the diagnosis of thyroid cancer were 0.86,93.3% and 91.7%,which were significantly higher than the sensitivity and specificity of each index(P<0.01).Conclusions:The combined detection of glactin-3,HMGB-1 and TSGF of thyroid cancer had good sensitivity and specificity.