脑出血昏迷病人继发多器官功能障碍综合征的危险因素分析

摘要

目的:探讨脑出血昏迷病人继发多器官功能障碍综合征(MODS)危险因素,为临床治疗提供参考.方法:选取88例脑出血昏迷病人分为2组,A组为继发MODS 48例,B组为未继发MODS 40例.对2组白细胞介素(IL)-1、IL-10等指标进行检测,并进行格拉斯哥昏迷评分、急性生理与慢性健康状况(APACHE-Ⅱ)评分,检测MODS情况并分析危险因素.结果:A组病人IL-1、IL-10、APACHE-Ⅱ评分、脑出血量及血糖等指标均高于B组(P<0.05～P<0.01),而格拉斯哥昏迷评分低于B组(P<0.01);A组病人APACHE-Ⅱ评分、IL-10、血糖以及脑出血量均为MODS的主要危险因素(P<0.05～P<0.01).结论:脑出血量、血清IL-10活性、APACHE-Ⅱ评分及血糖过高等因素是造成脑出血昏迷病人继发MODS的重要危险因素.%Objective:To investigate the risk factors of the multiple organ dysfunction syndrome(MODS)in patients with cerebral hemorrhage coma for providing a reference in clinical treatment.Methods:Eighty-eight patients with cerebral hemorrhage coma were divided into group A(48 cases with MODS)and group B(40 cases without MODS).The levels of interleukin(IL)-1 and IL-10 in two groups were detected.The scores of the Glasgow Coma Scale,acute physiology and chronic health evaluation(APACHE-Ⅱ)in two groups were measured,and the risk factors of MODS were analyzed.Results:The levels of IL-1 and IL-10,APACHE-Ⅱ score,cerebral hemorrhage amount,blood glucose level and other indicators in group A were higher than those in group B(P<0.05 to P<0.01),and the score of Glasgow Coma Scale in group A was lower than that in group B(P<0.01).The APACHE-Ⅱ score,IL-10,blood glucose levels,and cerebral hemorrhage amount were the main risk factors of MODS(P<0.05 to P<0.01).Conclusions:The cerebral hemorrhage amount,IL-10 level,APACHE-Ⅱ score,and high blood glucose are the main risk factors of MODS in cerebral hemorrhage patients.