血清维生素D水平在外周T细胞淋巴瘤患者预后中的意义

摘要

Objective:To detect the serum vitamin D level in patients with peripheral T-cell lymphoma ( PTCL ) , and its clinical significance. Methods:Fifty-one newly diagnosed PTCL patients and 20 healthy people were divided into the newly diagnosed group and control group, respectively. The serum expression levels of 25-hydroxy vitamin D [ 25 ( OH ) D ] in two groups was determined by chemiluminescence method. Results:The level of 25(OH)D in newly diagnosed group(20. 110 ng/mL) was lower than that in control group(48. 812)ng/mL(P<0. 01). The serum level of 25(OH)D in newly diagnosed group was positive correlation with the therapeutic efficacy(P<0. 05),and negative correlation with the clinical stage and IPI score(P<0. 01). Conclusions:The level of 25(OH)D is useful in estimating the therapeutic efficacy and prognosis in patient with PTCL.%目的:探讨血清维生素D在外周T细胞淋巴瘤(peripheral T-cell lymphoma,PTCL)中的表达水平及临床意义.方法:选取51例初诊PTCL患者(初治组)及正常健康人(对照组)20名,采用化学发光法测定血清25-羟基维生素D[25(OH)D]的表达水平.结果:PTCL患者血清25(OH)D的表达在初治组为20.110 ng/mL,低于对照组的48.812 ng/mL(P<0.01).初治PTCL患者血清25(OH)D的表达水平与疗效呈正相关关系(P<0.05),与分期、国际预后指数评分呈负相关关系(P<0.01).结论:监测血清25(OH)D的表达水平有助于非霍奇金淋巴瘤的疗效及预后评定.