肉苁蓉多糖对CCl4所致小鼠急性肝损伤的保护作用

摘要

Objective :To evaluate the protective effect of cistanche deserticolapolysaccharide (CDPS )on acute liver in_jury induced by the carbon tetrachloride(CCl4 )in mice .Methods:The liver injury model was established by CCl4 .Intra_gastric administration of different dosages of CDPS (400 mg/kg ,100 mg/kg) and Bifendate Pills (150 mg/kg) were used as the positive control .The Level of aspartate aminotransferase (AST) and alanine aminotransferase (ALT)in mouse ser_um ,as well as malondialdehyde(MDA) and superoxide dismutase (SOD) in mouse liver was determined .The results :Compared with that in the CCl4 model group ,the level of serum ALT and serum AST significantly dropped in the high -dosage CDPS group( P <0 .05) .There was no significant difference in the level of serum ALT and serum AST between the low -dosage CDPS group and the CCl4 model group .Compared with that in the CCl4 model group ,MDA level in the liver significantly dropped in different -dose CDPS groups( P <0 .05) and the activity of SOD significantly increased ( P<0 .05) .Conclusion :CDPS brings about a protective effect on the acute liver injury in mice induced by CCl4 .%目的：研究肉苁蓉多糖对CCl4所致小鼠急性肝损伤的保护作用。方法：采用CCl4急性肝损伤模型，通过小鼠灌胃给予高、低剂量的肉苁蓉多糖（400 mg／kg、100 mg／kg ），并以联苯双酯（150 mg／kg ）为阳性对照药，检测小鼠血清的丙氨酸氨基转移酶（ALT）、天冬氨酸转氨酶（AST）及肝脏中丙二醛（MDA）、超氧化物歧化酶（SOD）的含量。结果：肉苁蓉多糖高剂量组小鼠的血清ALT、AST与CCl4模型组相比显著降低（ P＜0．05），低剂量组ALT、AST与CCl4模型组相比差异无统计学意义，各剂量组MDA含量与模型组相比显著降低（ P ＜0．05）、SOD的活性显著增高（ P ＜0．05）。结论：肉苁蓉多糖对小鼠急性肝损伤具有一定的保护作用。