早产儿院内感染败血症高危因素及病原学分布分析

摘要

Objective:To analyze the high risk factors and aetiology distribution of premature infected with sepsis in hospital. Methods:A ret-rospective survey of 3 360 cases of premature in our hospital was conducted to analyze the risk factors and aetiology distribution of premature infected with sepsis in hospital. Results:There were 3 360 cases of premature, 56 cases infected with sepsis in hospital, and the nosocomial infection rate was 1. 67 %. The blood of the 56 cases premature infected with sepsis in hospital cultivated 61 strains of nosophyte, among which gram-negative bacteria accounted for 40. 98%, gram-positive bacterium accounted for 45. 90%, and epiphyte accounted for 13. 12%. Gram-negative bacte-ria mainly contained Klebsiella pneumoniae, gram-positive bacterium mainly contained coagulase negative staphylococcus. Conclusion:The main risk factors of premature infected with sepsis in hospital are birth weight ( less than 1 500 g) , mechanical ventilation, central venous catheterization and parenteral nutrition time. Main nosophyte are Klebsiella pneumoniae and coagulase negative staphylococcus.%目的：：分析早产儿院内感染败血症高危因素及病原学分布。方法：选取收治的3360例早产儿资料进行回顾性分析，分析早产儿发生院内感染败血症的危险因素及病原学分布。结果：3360例早产儿中发生医院感染败血症的患儿56例，院内感染发生率为1.67%。56例早产儿院内感染败血症血培养出病原菌61株，其中革兰氏阴性菌40.98%，革兰氏阳性菌45.90%，真菌13.12%。革兰氏阴性菌中以肺炎克雷伯杆菌为主；革兰氏阳性菌以凝固酶阴性葡萄球菌为主。结论：我院早产儿医院感染败血症的主要危险因素是出生体重﹤1500 g、机械通气、中心静脉置管和肠外营养时间；主要病原菌为肺炎克雷伯杆菌与凝固酶阴性葡萄球菌。