先天性感音性聋患者大脑皮层静息态功能磁共振研究

摘要

Objective The BOLD -fMRI(blood oxygenation level dependent functional magnetic resonance imaging)was used to observe the functional cortical activities of the bilateral cerebral hemispheres in 23 cases of chil_dren with congenital sensorineural hearing loss under resting state ,and to further explore the values of BOLD-fM_RI in patients with sensorineural hearing loss .Methods Twenty three children with congenital sensorineural hearing loss were included in the experimental group and 10 normal heating children were included as cronol group .The ALFF(amplitude of low -frequency fluctuation) method was used to analyze the image data ,and to compare the ex_perimental and control groups with bilateral cerebral cortex function activities for the quantitative analysis .ResuIts The resting state activity intensity in the left inferior temporal gyrus ,left fusiform gyrus ,right cingulate gyrus and left post central gyrus of the experimental group were significantly greater than those of in the corresponding intensi_ty cortex of the control group (P< 0 .01) .ConcIusion The cortex of sensory systems in children with congenital sensorineural deafness may have functional remodeling ,cerebral cortex of patients with sensorineural hearing loss may have perception compensation phenomenon .%目的：应用血氧水平依赖功能磁共振成像（blood oxygenation level dependent functional magnetic resonance imag ing ，BOLD－ fM RI）技术观察先天性感音神经性聋患者静息态双侧大脑半球皮层功能活动。方法对23例行人工耳蜗植入术的双侧先天性感音性聋患者（实验组）和10例听力正常者（对照组）行静息态BOLD—fMRI检查，采用fMRI低频震荡振幅（ALFF）方法比较实验组和对照组双侧大脑皮层功能活动情况，并进行定量分析。结果实验组大脑皮层左侧颞下回、左侧梭状回、右侧扣带回及左侧中央后回静息态激活强度明显大于对照组相应皮层的激活强度（P＜0．01）。结论先天性感音性聋患者感觉系统相关皮层可能发生了功能重塑，其大脑皮层存在知觉补偿现象。