肝豆灵对Wilson病患者前瞻性记忆功能的影响

摘要

Objective To investigate the effect of Gandouling on prospective memory function in patients with Wilson's disease.Methods A total of 64 patients with Wilson's disease were randomly divided into treatment group with 33 patients (treated with Gandouling and sodium dimercaptopropane sulfonate) and control group with 31 patients (treated with sodium dimereaptopropane sulfonate alone).The two groups were matched for age,degree of education,Mini-Mental State Examination score,and course of the disease.Time-and event-based prospective memory was evaluated before treatment and after 12 months of treatment.Results Both groups had a significant increase in time-based prospective memory (TBPM) score after treatment (P＜0.05),and the treatment group had a significantly greater increase in TBPM score than the control group (P＜0.05).Both groups showed no significant change in eventbased prospective memory (EBPM) score (＞7 points all the time) after treatment (P＞0.05),and there was no significant difference in the change in EBPM score after treatment between the two groups (P ＞ 0.05).Conclusion Gandouling can improve the prospective memory function of patients with Wilson's disease.%目的 观察肝豆灵对Wilson病(Wilson's disease,WD)患者前瞻性记忆功能的影响.方法 将WD患者随机分为治疗组(肝豆灵加二巯丙磺酸钠治疗)33例和对照组(二巯丙磺酸钠治疗)31例,两组患者年龄、文化程度、MMSE评分、病程相匹配.治疗前、治疗12周后,分别对两组患者基于时间的前瞻记忆(timebased prospective memory,TBPM)和基于事件的前瞻记忆(event-based prospective memory,EBPM)进行评估.结果 与治疗前比较,两组患者治疗后TBPM评分均显著增加(P＜0.05),治疗组TBPM评分差值显著高于对照组(P＜0.05);两组患者治疗前后EBPM评分(均大于7分)比较,差异无统计学意义(P＞0.05),两组EBPM评分差值比较,差异无统计学意义(P＞0.05).结论 肝豆灵可以改善WD患者前瞻性记忆功能.