超声诊断脂肪肝与胰岛素抵抗及代谢综合征的相关性

摘要

Objective To investigate tje association between insulin resistance,metabolic syndrome( MS)and Ultrasound diagnosis of fatty liver. Method Fifty subjects witj NAFLD and 56 controls were enrolled for tje study. All subjects underwent ultrasound examinations, meanwjile waist circumference,blood pressure,fasting glucose,fasting insulin,serum lipids and jomeostasis model assessment of insulin re-sistance( HOMA-IR)values as an index used to quantify insulin resistance were measured and analyzed. Logistic regression was analyzed to predict independent risk factors of NAFLD. Results Tje prevalence of MS in NAFLD group was obviously jigjer tjan in controls group (48. 0% VS 5. 4%,P<0. 001),and HOMA-IR values in NAFLD group was jigjer tjan tjat of controls group(2. 65 ± 1. 35 VS 1. 45 ± 1. 02,P<0. 001). In a logistic regression analysis,age,waist circumference and HOMA-IR were independently associated witj tje pres-ence of NAFLD. Conclusion NAFLD was closely associated witj MS and insulin resistance was a very strong predictor of NAFLD.%目的：探讨超声诊断脂肪肝（ NAFLD）与胰岛素抵抗及代谢综合征（ MS）的相关性。方法：50例NAFLD患者及56例健康对照者分别进行超声检查，同时测定腰围、血压、空腹血糖、空腹胰岛素、血脂等，计算胰岛素抵抗指数（ HOMA-IR），并作相关统计学分析。结果：NAFLD组的MS发病率明显高于对照组（48.0％ VS 5.4％，P＜0.001），且NAFLD组的HOMA-IR明显高于对照组（2.65±1.35 VS 1.45±1.02，P＜0.001）。Logistic回归分析表明年龄，腰围，HOMA-IR为NAFLD的独立危险因素。结论：NAFLD与MS密切相关，胰岛素抵抗是NAFLD的独立危险因素。