ORAL FORMULATIONS MIMETIC OF ROUX-EN-Y GASTRIC BYPASS ACTIONS ON THE ILEAL BRAKE; COMPOSITIONS, METHODS OF TREATMENT, DIAGNOSTICS AND SYSTEMS FOR TREATMENT OF METABOLIC SYNDROME MANIFESTATIONS INCLUDING INSULIN RESISTANCE, FATTY LIVER DISEASE, HYPERLIPIDEMIA, AND TYPE 2 DIABETES

摘要

The invention provides compositions, methods, and diagnostics for the treatment of metabolic syndromes. In an additional aspect of the invention, compositions and methods of treatment are calibrated to mimic the ileal brake response resulting from surgical intervention, e.g. RYGB, to control metabolic syndrome manifestations and thereby reverse or ameliorate the cardiovascular damage (atherosclerosis, hypertension, lipid accumulation, and the like) resulting from progression of metabolic syndrome. Combination medicaments that act synergistically on the ileal brake and the manifestations of metabolic syndrome are also disclosed.