24小时动态血压监测评价联合降压治疗

摘要

目的：运用动态血压监测（Ambulatory Monitoring of Blood Pressure，ABPM）评估两种联合降压方案：贝那普利加氨氯地平（以下称 A + C 组），贝那普利加氢氯噻嗪（以下称 A + D 组）的降压效果。方法：选择符合条件的高血压2级及以上患者共80人，随机分入 A + C 组和 A + D 组，服药8周后，用24小时动态血压监测评估降压效果；结果：两种联合方案不但能明显降低平均收缩压、舒张压，还能降低高血压晨峰（morning blood pressure surge，MBPS）和血压变异性（blood pressure variability，BPV），同时帮助恢复正常的“杓型曲线”。两组相比，A + C 组在降低 MBPS 上具显著优势，在降压有效率及恢复正常的“杓型曲线”方面稍有优势，但不显著。结论：A + C 和 A + D 联合降压治疗效果显著，能有效控制收缩压、舒张压、晨峰血压及 BPV，帮助恢复正常的血压变化曲线，A + C 组合可能在降压治疗上更具优势。%Objective We applied ambulatory blood pressure monitoring(ABPM)to evaluate two kinds of combination antihypertens-ive therapy:benazepril with amlodipine(A + C group),benazepril with DHCT(A + D group). Method 80 patients of 2th level hypertension whose conditions accord with our study were selected,they were divided into two groups randomly,and then evaluate the antihypertensive effect by ABPM 8 weeks after taking the medicine. Results The two kinds of combination antihypertesion therapy not only reduced average systolic blood pressure and diastolic blood pressure,but also reduced morning blood pressure surge(MBPS)and blood pressure variability (BPV). At the same time,the combination therapy could help to recovery the changes of blood pressure curves. And in our experiment,the combination of A + C group was more effective in reducing MBPS,and recovering the changes of blood pressure curves than the combination of A + D group,in addition,the former was notale. Conclusion The effect of two kinds of combination antihypertension therapy are all sig-nificantly,can control blood pressure,BPV,MBPS,and recovery the changes of blood pressure curves. The combination of benazepril with amlodipine have more. advantage in antihypertension probably.