目的：研究急性心肌梗死患者血糖水平与血清中NT-proBNP、hs-CRP表达的相关性，探讨应激性高血糖对心功能的影响及可能机制。方法：对既往无糖尿病病史的急性心肌梗死患者168例进行分析，根据入院后空腹血糖水平（＞7.0 mmol/L）分为血糖升高组（102例）和血糖正常组（66例），同时检测两组患者血清中NT-proBNP、hs-CRP的表达水平，观察两组中NT-proB-NP、hs-CRP表达的差异，以及NT-proBNP与hs-CRP表达的相关性。结果：NT-proBNP与hs-CRP在血糖升高组的表达[平均值分别为（1423±302.1）pg/ml和（27.13±3.23）mg/L]较血糖正常组[平均值分别为（623±164.2 pg/ml）和（13.48±2.87）mg/L]明显升高，且两者具有明显的相关性，差异有统计学意义（R=0.85 P＜0.05）。结论：应急血糖增高可促进急性心肌梗死后心功能不全的发生、发展，其机制可能与应急高血糖引起的炎性反应损伤有关。%objective To study the relationship between stress hyperglycemia induced by acute myocardial infarction and the expression of NT-pro BNP and hs-CRP,observe the influence of hyperglycemia on heart function and its mechanism. Method 168 patients were divided into two groups according to the glucose level:hyperglycemia group (>7. 0 mmol/L)and normal glucose group,observe the level of NT-pro BNP and hs-CRP in two groups,study the relative relationship between NT-proBNP and hs-CRP. Results The expression of NT-pro BNP and hs-CRP in hyperglycemia was higher than the normal glucose group,the expression of NT-proBNP was related to the expression of hs-CRP the difference was statistically signifcant(R=0. 85,P<0. 05). Conclusion Hyperglycemia is involved in the occurrence and devel-opment of cardiac insufficiency,its mechanism may be related to inflammation.
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