Objective: To explore the correlation of plasma level N-terminal pro-B-type natriuretic peptide (NT-proBNP) in patients with non-diabetic acute myocardial infarction (AMI) combining stress hyperglycemia. Methods: A total of 327 non-diabetic AMI patients treated in our hospital from 2012-02 to 2014-05 were studied. The patients were divided into 2 groups according to fasting blood glucose level:Stress group, the patients with blood glucose≥7.0 mmol/L, n=182 and Non-stress group, the patients with blood glucose<7.0 mmol/L, n=145. The basic clinical condition, laboratory tests within 24 hours of onsets, echocardiography and 24 h dynamic electrocardiogram were examined;the incidence of major adverse cardiovascular events (MACE) including arrhythmia, heart failure, cardiac shock and sudden cardiac death in 2 weeks of onsets were analyzed and compared between 2 groups. Results: The patients’ age, gender, history of hypertension, smoking, drinking, and blood levels of TC, TG, HDL-C, LDL-C were similar between 2 groups, P>0.05. Plasma levels of NT-proBNP, CK-MB, MYO, ultra-TnI, ALT, AST and blood glucose level were signiifcantly different between 2 groups P<0.01. NT-proBNP level was positively related to ultra-TnI (r2=0.811, r=0.901, P<0.01). Stress group presented obviously higher incidence of MACE (P<0.05), lower LVEF (P<0.01), and signiifcantly increased left ventricular end diastolic diameter, left ventricular end systolic diameter (P<0.01) than those in Non-stress group. Conclusion: Plasma levels of NT-proBNP may judge the severity and evaluate recent prognosis in patients with non-diabetic AMI combining stress hyperglycemia, it could be used as a risk indicator for relevant patients in clinical practice.%目的：探讨氨基末端B型利钠肽原（NT-proBNP）与非糖尿病急性心肌梗死（AMI）合并应激性高血糖相关性。 方法：选取2012-02至2014-05在我院心内科住院诊断为非糖尿病AMI的患者327例，按空腹血糖水平分为非糖尿病AMI合并应激性高血糖组（应激组）182例和非糖尿病AMI未合并应激性高血糖组（非应激组）145例。统计患者基本临床资料及入院24 h内实验室检查、超声心动图及24小时动态心电图检查结果，并记录住院2周内心律失常、心力衰竭、心原性休克、心原性猝死等主要不良心血管事件发生率，分析NT-proBNP与非糖尿病AMI合并应激性高血糖的相关性。 结果：年龄、性别、高血压史、吸烟史、饮酒史、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）在应激组和非应激组之间比较差异无统计学意义（ P<0.05），NT-proBNP、肌酸激酶MB同工酶（CK-MB）、肌红蛋白（MYO）、超敏肌钙蛋白I（ultra-TnI）、丙氨酸氨基转氨酶（ALT）、天门冬氨酸氨基转移酶（AST）、血糖（Glu）在应激组和非应激组之间比较差异有统计学意义（ P<0.01）。NT-proBNP与ultra-TnI呈正相关（r2=0.811，P<0.01）。应激组主要心血管不良事件发生率明显高于非应激组（ P<0.05）；左心室射血分数（LVEF）明显低于非应激组（ P<0.01）；左心室舒张末期内径（LVDd）、左心室收缩末期内径（LVDs）明显高于非应激组（ P<0.01），差异均有统计学意义。 结论：NT-proBNP水平可以判断非糖尿病AMI合并应激性高血糖患者病情危重程度，并对近期预后做出评估。
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