目的：分析低分子量肝素对重症急性胰腺炎患者的临床治疗效果。方法：将40例患者分为两组，19例用 LMWH 治疗组（H 组），21例用常规治疗组（G 组），观察并对比其治疗前后的凝血时间、凝血酶原时间、纤维蛋白原含量以及 IL -8、IL -10和 NF - kB 血清蛋白酶的水平。结果：H 组的凝血和凝血酶原时间和血清中的纤维蛋白原含量都显著比 G 组要高，差异有统计学意义（P ＜0.05）；H 组 CRP、降钙素原及脂肪酶含量都比 G 组低，差异有统计学意义（P＜0.05）；G 组发生并发症的几率明显高于 H 组，差异有统计学意义（P ＜0.05）。结论：采用低分子量肝素（LMWH）对重症急性胰腺炎（SAP）的治疗有一定疗效，但是其疗效和安全性还需要进行大量的临床实验进行证实。%Objective To analyze the clinical effect of low molecular weight heparin in the treatment of severe acute pancrea-titis. Method 40 patients were divided into two groups,19 cases with LMWH treatment group(H Group)and 21 cases of con-ventional treatment group(G group),the coagulation time,prothrombin time(PT),fibrinogen content and of IL - 8,IL - 10 and NF KB and serum protein level were observed and compared before and after the treatment. Results Clotting and prothrombin time and serum fibrinogen content in group H were significantly higher than that in group G,the different was statistically signifi-cant(P < 0. 05);the CRP,calcitonin and lipase of group H were lower than that of group G,the different was statistically signif-icant(P < 0. 05);the occurrence rates of complications of group G was significantly higher than that of H group,the different was statistically significant(P < 0. 05). Conclusion Low molecular weight heparin(LMWH)is effective in the treatment of severe acute pancreatitis(SAP),but its efficacy and safety need to be confirmed by a lot of clinical trials.
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