Objective To study the clinical effect of caffeine citrate and mechanical ventilation in premature infants with apnea.Method 94 premature infants with apnea were selected.All of the cases adopted the mechanical ventila-tion.The subjects were divided into two groups according to the admission time of hospital,47 cases in each group.The control group took Aminophylline;the observation group took caffeine citrate.The clinical effect,frequency of apnea, time of NCPAP,time of oxygen uptake and adverse reactions were observed.Results The total effective rate for observa-tion group (89.36%)was higher than control group (76.60%)(P <0.05);before surgery,the frequency of apnea for two groups was not significantly different (P >0.05);after surgery,the frequency of apnea,time of NCPAP,time of oxygen uptake for observation group was better than control group (P <0.05);the adverse event rate of observation group (12.77%)was lower than control group (27.66%)(P <0.05).Conclusion The caffeine citrate has an obvi-ous effect in premature infants with apnea,improves the clinical symptoms and reduces the adverse event rate.It is wor-thy of clinical application and promotion.%目的：研究呼吸暂停早产儿采用枸橼酸咖啡因联合机械通气的治疗效果。方法：临床纳入94例呼吸暂停早产儿，所有患儿均采用机械通气辅助呼吸。按入院顺序将患儿分为两组各47例。其中47例患儿联合氨茶碱进行治疗作为对照组，另47例患儿联合枸橼酸咖啡因进行治疗作为观察组。观察两组患儿的治疗效果、呼吸暂停频率、NCPAP 使用时间、氧气使用时间及不练反应。结果：观察组、对照组总有效率分别为89.36％、76.60％，观察组明显较高，差异有统计学意义（P ＜0.05）。治疗前两组患儿呼吸暂停频率差异，无统计学意义（P ＞0.05）；治疗后观察组呼吸暂停频率、NCPAP 使用时间以及氧气使用时间均优于对照组，差异有统计学意义（P ＜0.05）。观察组、对照组不良反应发生率分别为12.77％、27.66％，观察组明显低于对照组，差异有统计学意义（P ＜0.05）。结论：枸橼酸咖啡因是治疗早产儿呼吸暂停的有效药物，症状改善快、不良反应低，值得临床应用及推广。
展开▼
