Objective To explore the quality and characteristics of the medicine in the prescription of treating thyroid nodules and to lay a foundation for the treatment of thyroid nodules by traditional Chinese medicine and western medicine. Methods By means of frequency analysis, cluster analysis and database such as Wan Fang, CNKI and VIP, the original literature on the treatment of thyroid nodules by traditional Chinese medicine was searched and analyzed. Combining the theory of TCM with the corresponding method of prescription and syndromes, this paper analyzes the prescription and the law of medicine used for internal treatment of avascular necrosis of femoral head, and analyzes the regularity of prescription of TCM in treating thyroid nodule with reference to evidence-based medicine, theory of traditional Chinese medicine and corresponding method of prescription and syndromes. Results A total of 137 prescriptions for internal treatment of thyroid nodules were collected and 729 flavors were used, among which the top ten Chinese medicines with the highest frequency were bupleurum, curcuma, cyperus, poria, peony, prunella, bitter orange, fritillaria, green tangerine peel, and prepared pinellia tuber. To describe "medicinal" relating to statistics found that thyroid nodule is the main drug of "cold" drugs, cold resistance and cold drugs accounted for 49.4%, followed by flat and warm drugs, the gender accounted for 36.3% of the total medicine medicinal properties;Drug use in grape, for the most, accounts for 35.8%, followed by bitter, bitter herbs, total accounted for 50.7% of all drug ingredients, the use of other flavors are less; Meridian distribution to the liver by the drugs as the most, accounted for 24.7%, and then is the bravery and heart, lung, spleen by the drugs, the three meridian distributions accounting for 77.9% of all the drugs. Conclusion By summarizing and analyzing the law of drug quality and flavor returning to the meridian, it was found that the disease of thyroid nodule prescription was located in the liver, based on the dysfunction of liver, spleen and kidney, and qi stagnation and blood stasis and phlegm coagulation were the most important etiological factors of the disease.%目的 探讨治疗甲状腺结节方剂药物性味、归经的用药特征,从而中西医治疗奠定治疗甲状腺结节奠定相应的基础.方法 采用频数分析、聚类分析等统计方法,通过万方、CNKI以及维普等数据库,对检索到的近现代医家采用中医药的方法治疗甲状腺结节的原始文献进行检索与分析,结合中医中药的理论与方证对应法分析股骨头缺血性坏死内治方药的组方以及用药规律.借鉴循证医学、中医中药理论以及方证对应法分析中医药治疗甲状腺结节的组方规律.结果 通过检索共收集共收集甲状腺结节内治方剂137首,用药729味,其中频次最高的前十味中药分别是柴胡、郁金、香附、茯苓、白芍、夏枯草、枳壳、贝母、青皮、法半夏.对所涉及到"药性"进行描述统计发现甲状腺结节用药主要是寒性药物,寒性及微寒药物占到了49.4%,其次是平性和温性药物,平性和温性占全部用药药性的36.3%;此外,甘味用药所占比例最大为35.8%,其次为苦、辛味药,比例经计算后为全部用药的50.7%,其他药味会产生较低的频次,而主要药物为归经药物,占24.7%,而后是胆经和心、肺、脾经的药物,以上三类归经占到了全部用药归经的77.9%.结论 通过对药物性味归经的规律进行总结分析发现甲状腺结节方剂用药其病位在肝,以肝脾肾三脏功能失调为本,气滞血瘀痰凝为该病最关键的致病因素的病因病机.
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