藿香最早的文献出处可追溯到东汉杨孚《异物志》,作为药名在本草中单列一条始见于宋朝《证类本草》.长期以来的历史,形成了土藿香与广藿香二者临床并用的局面,阐释二者的区别,厘清二者的入药史有重要意义.本研究通过系统检索《中华医典》数据库和历代本草古籍及名家医著,对土藿香与广藿香相关古籍记载进行了研究.发现藿香入药最早见于《千金要方》《外台秘要》,广泛应用于临床则是宋代《太平惠民和剂局方》,以藿香正气散为代表.藿香产于东南亚,后移栽于岭南,从香料演变为中药,在清代温病学派盛行时期,更是成为重要中药,于明代定名为"广藿香",以示道地.广藿香之名最早见于明代王肯堂《医学穷源集》,比此前观点所认为的首见于民国《增订伪药条辨》提前了300多年.与之相对的江浙一带产生土产藿香,最终定名土藿香.二者历史上共同演进.%Objective The earliest literature origin of wrinkled giant hyssop dates back to Yiwuzhi which was written by YANG Fu in the Eastern Han Dynasty, and as a medicine name listed separately on herbal beginning in the Song Dynasty in Materia Medica Arranged According to Pattern. For a long period of time, a situation that the Agastache rugosa and Pogostemon cablin used clinically at the same time formed. It's significantly important to explain the difference and clarify the medicinal history between the two. This research studies ancient records relevant to Agastache rugosa and Pogostemon cablin by systematically retrieving Zhonghua Yidian database, and all previous dynasties herbal ancient books and famous medical works, discovering that Huoxiang first used as a medicine recorded in Qianjin Yaofang and Waitai Miyao, and widely used clinically in the Song Dynasty Taiping Huiming Heji Jufang, in which Huoxiang Zheng qi San was regarded as a represent. wrinkled giant hyssop originates in Southeast Asia, and then was transplanted in Lingnan, evolving into a traditional Chinese medicine from a spice. Further it becomes an important traditional Chinese medicine in the Qing Dynasty when febrile diseases prevailed. wrinkled giant hyssop named as "Guanghuoxiang" in the Ming Dynasty to show its genuine. The name of "Guanghuoxiang"first recorded in WANG Kentang Yixue Qiongyuan Ji in the Ming Dynasty, 300 years earlier than the previous view that the first historical record of "Guanghuoxiang" is in the republic of China Zengding Weiyao Tiaobian. Meanwhile, the "huoxiang" originating in Jiangsu and Zhejiang named "tuhuoxiang" finally.
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