目的 探讨检测外周血循环内皮细胞(CEC)在晚期食管癌放化疗疗效评估中的价值.方法 66例晚期食管鳞癌患者分为化疗组(21例,用PF方案)、放疗组(18例,剂量60～70Gy/6周)和放化疗联合组(27例).用流式细胞术检测外周血CEC.结果 晚期食管癌患者CEC基础值较健康者高[(20.84±7.31)个/μl vs.(11.14±3.07)个/μl](P<0.01).治疗前,3组CEC数相仿;治疗后,放化疗联合组CEC较治疗前显著降低[(14.39±5.36)个/μvs.(20.22±7.01)个/μl](P<0.01),其他两组降低不明显.结论 检测治疗前外周血CEC有可能成为预测晚期食管癌患者放化疗疗效的指标.%Objective To investigate the significance of detecting circulating endothelial cell (CEC) in evaluating the efficacy of radiochemotherapy in the patients with advanced esophageal cancer. Methods Sixty-six patients with advanced esophageal cancer were divided into groups of chemotherapy(group A, 21 cases, PF regimen), radiotherapy(group B, 18 cases, 60 ～ 70 Gy/6w) and chemoradiotherapy(group C,27 cases). The CECs were detected with flow cytometry. Results The CECs were higher in the patients with advanced esophageal cancer than those in the healthy people [(20.84±7.31) pieces/μl vs. (11.14±3.07) pieces/μl](P＜0.01). Before treatment, the CECs of three groups were similar. The CECs of group C were lower after treatment than those before [ ( 14.39 ±5.36) pieces/μl vs. (20.22±7.01) pieces/μl](P＜0.01) ,which were not significantly decreased in groups of A and B. Conclusion Detection of CECs in periphyral blood could be taken as a marker in evaluating the efficacy of radiochemotherapy in the patients with advanced esophageal cancer.
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