帕瑞昔布超前镇痛对烧伤患者术后疼痛及血清IL-6和IL-1O表达的影响

摘要

目的 探讨帕瑞昔布超前镇痛对术后镇痛及血清IL-6和IL-10水平的影响.方法 36例烧伤患者随机均分为两组:A组术毕前50 min缓慢静注帕瑞昔布40 mg;B组不施行超前镇痛.术后不行自控镇痛,在患者主诉疼痛难忍时肌注哌替啶75 mg/次.记录术后4、8、12、24 h静息VAS疼痛评分,并用放射免疫分析方法测定血清IL-6和IL-10浓度.结果 A组术后4、8、12h的VAS评分均显著低于B组(P＜0.01),血清IL-6水平低于B组,而IL-10水平高于B组(P＜0.05).结论 术毕前预用帕瑞昔布可明显减少烧伤术后疼痛和炎性反应.%Objective To study the preemptive analgesia and effects of parecoxib on IL-6 and IL-10 expressions in burned patients. Methods Thirty-six burned patients were equally randomized to two groups of A( injected parecoxib 40 rag at 30 min before the end of operation) and B( without parecoxib as the control). Intramuscular injection of pethidine 75 mg was performed after operation if necessary. Postoperative pain was scored by VAS at 4, 8, 12, and 24 h after operation and the expressions of serum IL-6 and IL-10 were detected by radioimmunoassay. Results At 4,8 and 12 h after operation, the VAS scores were significantly less in group A than those in group B(P<0. 01), serum IL-6 was lower,but IL-10 was higher,in group A than those in group B(P<0. 05). Conclusion Preemptive analgesia with parecoxib 40 mg can effectively attenuate postoperative pain and inflammatory cytokine response after surgery for bum.