2型糖尿病患者微量白蛋白尿与心血管危险因素的相关性

摘要

Objective To evaluate the correlation of microalbuminuria (MAU) with cardiovascular risks in patients with type 2 diabetes mellitus(T2DM). Methods On the basis of the ratio of urine albumin to criatinine(ACR) ,483 T2DM patients were assigned to two groups of A(248 cases, ACR< 30 mg/g) and B(235 cases, ACR 30-300 mg/g). Serum total cholesterol (TC), triglyceride(TG), high density lipoprotein cholesterol (HDL-C),low density lipoprotein cholesterol (LDL-C),glycolated hemoglobin(HbAlc), fasting blood glucose(FBG), postprandial blood glucose (PBG),fasting insulin(Fins) were detected and compared. Results Serum TG, TC, LDL-C, FBG, PBG and Fins were significantly higher in group B than those in group A(P<0. 05). The incidence rates of hypertension, coronary heart disease and atherosclerosis were higher in group B than those in group A(P<0. 05). BMI, SBP, TC, FBG were the independent risk factors for MAU. Conclusion T2DM patients with MAU often have obesity, hypertension, hyperglycemia, lipid disorders and increased risks for cardiovascular diseases.%目的 探讨2型糖尿病(T2DM)患者微量白蛋白尿(MAU)与心血管危险因素的相关性.方法 T2DM患者483例,根据尿白蛋白与肌酐比值(ACR)分为正常白蛋白尿组(A组,248例,ACR＜30 mg/g)和MAU组(B组,235例,ACR 30-300 mg/g).检测两组血清甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、糖化血红蛋白(HbAlc)、空腹血糖(FBG)、餐后2-h血糖(PBG)、空腹胰岛素(FIns).结果 与A组比较,B组TG、TC、LDL-C、FBG、PBG、FIns均明显增加(P＜0.05)；高血压病、冠心病、动脉粥样硬化的发病率升高(P＜0.05).体重指数、收缩压、TC、FBG是发生MAU的独立危险因素.结论 T2DM患者MAU易合并超重、高血压、糖脂代谢紊乱,心血管疾病风险增加.