2型糖尿病患者蛋白尿与糖尿病视网膜病变的关系

摘要

目的 探讨2型糖尿病(T2DM)患者尿白蛋白/肌酐比值(UACR)与糖尿病视网膜病变(DR)的关系.方法 152例T2DM患者根据UACR均分为UACR正常(A)组(UACR＜30 mg/g)和UACR异常(B)组(UACR≥30 mg/g),根据糖尿病病程再分为病程＜10年(C)组(87例)和病程≥10年(D)组(65例).检测血糖、糖化血红蛋白,计算UACR.结果 B组DR患病率53.9％,明显高于A组的28.9％ (P＜0.05),B组发生DR的危险是A组的2.875倍(95％可信区间为1.471-5.620).C组中,UACR异常患者的DR患病率51.6％,明显高于UACR正常者的26.8％(P＜0.05),且前者发生DR的危险是后者的2.916倍(95％可信区间为1.162-7.314).结论 病程较短且UACR异常的T2DM患者发生DR的风险较高.%Objective To investigate the association between the ratio of urinary albumin to creatinine( UACR) and diabetic retinopathy(DR) in patients with type 2 diabetes mellitus(T2DM). Methods A total of 152 T2DM cases was equally assigned into two groups of A(UACR <30 mg/g} and B (UACR≥30 mg/g) ,or divided into two groups of C (87 cases with T2DM <10 years) and D (65 cases with T2DM^10 years). Blood glucose(BG) and glycosylated hemoglobin(HbAlc) were measured and UACR was calculated. Results The incidence rate of DR was higher in group B than that of group A (53. 9% vs. 28. 9%)(P<0. 05) and the DR risk of group B was 2. 875 times as much as that of group A(95% confidence interval 1. 471-5. 620). In group Cthe incidence rate of DR was higher in the cases with UACR≥30 mg/g than those with UACR<30 mg/g(51. 6% vs. 26. 8%) (P<0. 05),and the DR risk in the former was 2. 916 times of the latter(95% confidence interval 1. 162-7. 314). Conclusion The patients with T2DM <10 years and abnormal UACR have higher risk for DR.