手术对胃肠恶性肿瘤患者免疫功能的影响

摘要

目的：探讨手术对胃肠恶性肿瘤患者免疫功能的影响。方法胃肠恶性肿瘤患者37例（A组），采用流式细胞仪检测外周血CD25＋、CD28＋、诱导共刺激分子（ICOS ）和程序性死亡分子1（PD‐1）的表达，与23例健康体检者（B组）比较。A组中的13例接受了肿瘤根治术。结果 A组CD25＋、CD28＋、ICOS和PD‐1表达水平均低于B组（P＜0．05）。与术前相比，13例患者术后外周血CD25＋和CD28＋的表达水平升高（P＜0．05），而ICOS和PD‐1表达水平手术前后无统计学差异（P＞0．05）。结论胃肠恶性肿瘤患者免疫功能明显降低，手术切除肿瘤可改善患者的免疫功能。%Objective To investigate the effects of surgery on the immune function in the patients with gastrointestinal cancer .Methods Serum levels of CD25+ ,CD28+ ,inducible co‐stimulator(ICOS) and programmed cell death‐1(PD‐1) in peripheral blood were detected by flow cytometry in 37 patients with gastrointestinal cancer(group A) and 23 healthy people(group B) .Of group A ,13 cases underwent radical surgery .Results Serum levels of CD25+ ,CD28+ ,ICOS and PD‐1 in peripheral blood were significantly lower in group A than those in group B ( P<0 .05 ) . Compared to before ,serum levels of CD25+ and CD28+ were significantly elevated after operation (P<0 .05) ,but the expressions of ICOS and PD‐1 were not significantly changed ( P>0 .05 ) . Conclusion The immune function of patients with gastrointestinal cancer is significantly reduced , which is effectively improved after resection of gastrointestinal cancer .