新辅助治疗联合外科手术治疗局部中晚期食管癌

摘要

Objective To investigate the feasibility and safety of preoperative neoadjuvant chemoradiotherapy followed by surgery in the treatment of advanced esophageal carcinoma .Methods Preoperative neoadjuvant chemoradiotherapy with dorseyhesai + cisplatin scheme and conventional dose radiotherapy was performed in 11 patients (group A ) with clinical stage Ⅲ A‐Ⅲ C esophageal squamous carcinoma ,which was followed by surgical resection .The results were compared to those of 20 matched patients(group B) ,who underwent surgery without preoperative neoadjuvant chemoradio‐therapy .Results The operative time ,intraoperative blood loss and numbers of metastatic lymph nodes were less in group A than those in group B [(233.6 ± 19.9) min vs .(257.3 ± 28.9) min ,(160.9 ± 36.4) ml vs .(216.5 ± 56.4) ml and (1.3 ± 0.9) pieces vs .(2.3 ± 1.4) pieces](P<0 .05) .Conclusion Preoperative neoadjuvant chemoradiotherapy is feasible and safe in the treatment of advanced esophageal carcinoma with good short‐term outcomes .%目的：探讨术前行新辅助治疗（包括新辅助放化疗和新辅助化疗）联合外科手术治疗中晚期食管癌的可行性和安全性。方法ⅢA‐ⅢC期局部中晚期食管鳞癌患者11例（A组），术前完成多西他赛＋顺铂方案的新辅助化疗，同期给予常规分割剂量放疗；然后行食管癌切除术。选择病情相当，单纯接受手术治疗的的20例患者（B组）作对照，比较两组的疗效。结果 A组手术时间、术中出血量和淋巴结转移枚数均少于B组[（233.6±19.9） min vs ．（257.3±28.9） min、（160.9±36.4）mlvs．（216.5±56.4）ml和（1.3±0.9）枚 vs．（2.3±1.4）枚]（P＜0．05）。结论新辅助治疗联合外科手术治疗中晚期食管癌安全可行，近期临床疗效确切。