溶栓后行经皮冠状动脉介入治疗对AMI患者心功能及血清MMP-9、PS水平的影响

摘要

Objective To investigate the effect of percutaneous coronary intervention (PCI) after thrombolysis on cardiac function and serum levels of matrix metalloproteinase-9 (MMP-9) and P-selectin (PS) in patients with acute myocardial infarction (AMI).Methods 64 patients with AMI admitted to our hospital from September 2016 to October 2018 were randomly divided into observation group and control group,32 cases in each group.The control group was treated with direct PCI within 90 minutes after admission,while the observation group was treated with intravenous thrombolysis before selective PCI.The therapeutic effects of the two groups were compared.Results IRA recanalization rate and relief rate of chest pain in the observation group were significantly higher than those in the control group (P＜0.05);after 30 days of treatment,the level of LVEF in the observation group was significantly higher than that in the control group (P＜0.05);5 days after PCI,the levels of MMP-9 and PS in the observation group were significantly lower than those in the control group (P＜0.05).Conclusion PCI after thrombolysis can effectively improve myocardial reperfusion in a short time,protect cardiac function,and significantly reduce serum MMP-9 and PS levels in patients with AMI.%目的 探讨溶栓后行经皮冠状动脉介入(PCI)治疗对急性心肌梗死(AMI)患者心功能及血清基质金属蛋白酶-9(MMP-9)、P选择素(PS)水平的影响.方法 收集本院自2016年9月至2018年10月收治的64例AMI患者,按随机数字表法分为观察组与对照组各32例.对照组入院后90 min内立即予以直接PCI治疗,观察组入院后先给予静脉溶栓治疗,之后行择期PCI治疗,比较两组治疗效果.结果 观察组IRA再通率、胸痛症状缓解率均明显高于对照组(P＜0.05);治疗30 d后,观察组LVEF水平明显高于对照组(P＜ 0.05);PCI术后5d,观察组血清MMP-9、PS水平均明显低于对照组(P＜0.05).结论 溶栓后行PCI治疗能够短时间内有效改善AMI患者心肌组织再灌注,保护心功能,显著下调血清MMP-9、PS水平.