男性甲功异常患者甲功五项变化与血清性激素的相关性研究

摘要

目的 探究男性甲状腺功能异常患者的甲功五项变化与血清性激素的相关性.方法 选择从2017年3月至2018年3月在本院接受治疗的122例甲状腺功能障碍患者和58例正常健康男性作为对照组进行研究.患者分为甲亢组62例和甲减组60例,甲亢组给予甲硫咪唑片治疗,甲减组给予左甲状腺素钠片治疗.在治疗前后对比三组甲功五项的指标来评价治疗效果,并分析三组血液性激素的水平.结果 治疗后甲亢组与甲减组患者的甲功五项指标均有明显改善,并与对照组比较差异无统计学意义(P＞0.05).治疗前,甲亢组的雌二醇(E2)、睾酮(T)和垂体泌乳素(PRL)与对照组相比均较高(P＜0.05),促黄体生成激素(LH)和促卵泡成熟素(FSH)含量无统计学差异;甲减组E2和PRL水平比对照组高,而T的含量比对照组低,差异均有统计学意义(P＜0.05),LH和FSH含量无统计学差异.治疗后,甲亢组的E2浓度为(21.83±2.91) ng/L,T浓度为(17.96±5.75) μg/L,LH浓度为(4.31±2.70) mIU/ml,PRL浓度为(13.26±4.16) μg/L,四种性激素水平与治疗前相比均有明显改善(P＜0.05);治疗后甲减组的E2浓度为(22.63±3.72) ng/L,T浓度为(16.40±2.15) μg/L,PRL浓度为(14.77±3.65) μg/L,三种性激素水平与治疗前相比均有明显改善(P＜0.05).两组治疗后五项性激素水平均与对照组水平相近.结论 甲状腺功能障碍的男性患者血清性激素水平紊乱,这一变化与甲状腺激素水平有关.甲状腺激素可能是通过干涉E2、T及PRL的浓度来进一步影响性功能的.%Objective To explore the correlation between the five items of thyroid function and serum sex hormones in male patients with thyroid dysfunction.Methods A total of 122 male patients with thyroid dysfunction who were treated in our hospital from March 2017 to March 2018 were enrolled,and 58 normal healthy men as controls.The patients were divided into 62 cases of hyperthyroidism and 60 cases of hypothyroidism.The hyperthyroidism group was treated with methimazole tablets,and the hypothyroidism group was treated with levothyroxine sodium tablets.Before and after treatment,the five items of thyroid function of the three groups were compared to evaluate the therapeutic effect,and the levels of serum hormones of the three groups were analyzed.Results After treatment,the five items of thyroid function in the hyperthyroidism group and the hypothyroidism group were significantly improved,and there were no statistically significant differences between the two groups and the control group (P＞0.05).Before treatment,estradiol (E2),testosterone (T),and pituitary prolactin (PRL) in the hyperthyroidism group were higher than those in the control group (P＜0.05),and there were no statistically significant differences in the levels of luteinizing hormone (LH) and folliclestimulating hormone (FSH) (P＞0.05).The levels of E2 and PRL in the hypothyroidism group were higher than those in the control group,while the concentration of T was lower than that in the control group (P＜ 0.0,5),there were no statistically significant differences in the concentration of LH and FSH (P＞0.05).After treatment,the E2 concentration of the hyperthyroidism group was (21.83±2.91) ng/L,the T concentration was (17.96±5.75) μg/L,the LH concentration was (4.31±2.70) mIU/ml,and the PRL concentration was (13.26±4.16) μg/L,the levels of four sex hormones were significantly improved compared with those before treatment (P＜0.05);the E2 concentration in the hypothyroidism group was (22.63±3.72) ng/L,and the T concentration was (16.40±2.15) μg/L,the PRL concentration was (14.77±3.65) μg/L,the three sex hormone levels were significantly improved compared with those before treatment (P＜0.05).After treatment,the levels of five sex hormones in the two groups were similar to those in the control group.Conclusions Male patients with thyroid dysfunction often have disordered serum sex hormone levels,which may be associated with thyroid hormone levels.Thyroid hormone may further affect sexual function by interfering with the concentrations of E2,T,and PRL.