目的 观察不同剂量芬太尼联合丙泊酚用于人工流产术中的麻醉效果.方法 选择自愿要求行人工流产术的早孕妇女178例,并随机分为对照组与观察组,每组各89例,其中观察组单次静注芬太尼1 μ g·kg-1及内泊酚1.5 mg·kg-1;对照组单次静注芬太尼2 μg·kg-1及丙泊酚1.5 mg·kg-1.观察两组妇女的麻醉起效时间、苏醒时间、呼吸抑制情况及不良反应.结果 观察组麻醉起效时间为(1.2±0.5)min,明显快于对照组(1.3±0.5)min;意识恢复时间对照组为(7.8±1.8)min,明显慢于观察组(6.4±1.6)min;两组用药后SPO2、RR均下降,但对照组发生率明显高于观察组;两组术中术后均无严重的不良反应发生.结论 浓度为1μg·kg-1芬太尼联合1.5 mg·kg-1丙泊酚用于人工流产术中,既可以加强镇痛,提高麻醉效果,又可以明显地减少丙泊酚的用量,使麻醉诱导和苏醒更加迅速,并不加深丙泊酚的呼吸、循环抑制作用,是一种较好的人工流产术的麻醉方法 .%Objective To explore the anesthetic effects of different doses of fentanyl combined with propofol for artificial abortion. Methods 178 women in first trimeter who requested artificial abortion were randomly assigned to receive single intravenous injection of fentanyl of 2 μg.kg-1 and propofol of 1.5mg.kg-1 (89 women, control group) or fentanyl of 1 μg. kg-1 and propofol of 1.5 mg.kg-1 (89 women, study group). The onset time of anaesthesia, time to regaining consciousness, respiratory depression, and adverse reactions were noted. Results The onset time of anaesthesia was shorter in the study group than in the control group [(1.2 ± 0.5)min vs. (1.3 ± 0.5)min]; time to regaining consciousness was longer in the control group than in the study group[(7.8 ± 1.8) min vs.(6.4 ± 1.6)min]; The rate of decrease in SPO2and RR was obviously higher in the control group than in the study. No serious adverse reactions occurred intraoperatively and postoperatively in both groups. Conclusions Fentanyl of lμg.kg-1 combined with propofol of 1.5mg.kg-1, a better anaesthetic method for artificial abortion, can enhance the effects of analgesia and anaesthesia, significantly reduce the amount of propofol use, resulting in shorter period of anesthetic induction and consciousness recovery, but does not enhance the effects of propofol on inhibition of respiration and circulation.
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