婴幼儿轮状病毒肠炎并心肌、肝脏损害临床研究

摘要

目的 探讨腹泻患儿轮状病毒感染与心肌、肝脏损害的关系.方法 对321例住院腹泻患儿用胶体金法检测粪便轮状病毒抗原并做心肌酶及肝功检测.结果 观察组(粪便轮状病毒抗原检测阳性)与对照组(粪便轮状病毒抗原检测阴性)心肌损害及肝损害的发生率比较,观察组明显高于对照组,差异有显著性(P值<0.05);全部病例中,小年龄组较大年龄组心肌损害及肝功损害发生率高,同年龄段中观察组的肝损害和心肌损害发生率明显高于对照组.对比差异有显著性(P值<0.05);全部病例中,随着脱水程度的增加,心肌酶和肝功能异常率有增高趋势,相同脱水程度情况下观察组的肝损害和心肌损害发生率明显高于对照组,两组对比差异有显著性(P值<0.05);全部病例中心肌酶及肝功能指标治疗前、后的对比有显著性差异(P值<0.05).结论 轮状病毒感染常合并心肌损害及肝损害,且年龄小者受损害的机率较大,随着脱水程度的增加,心肌酶和肝功能异常率有增高趋势.临床医生对腹泻患儿应注意粪便轮状病毒抗原及心肌酶、肝功的检测,并给予及时有针对性的治疗.%Objective To investigate the diarrhea rotavirus infection and cardiac muscle, liver damage relations.Methods 321 oases of hospitalized children with diarrhea were detected using colloidal gold and do stool rotavirus antigen detection of myocardial enzymes and liver function.Results The obser- vation group ( stool rotavirus antigen test positive ) and the control group ( stool rotavirus antigen test negative ) myoeardial injury incidence of liver damage compared to the observation group was significantly higher, the difference was significant ( P<0.05 ); Among all group, there are a higher incidence of myoeardial injury and liver damage in the small age group than in the older age group, there is a significant difference ( P<. 0.05 ).Among all groups, enzymes and liver function abnormal rate increased tendency with the degree of dehydration increases, there was a significant difference ( P< 0.05); Myocardial enzymes and liver function parameters before and after treatment in contrast to a significant difference( P<0. 05 ).Conclusions Rotavirus infection is often associated with myoeardial damage and liver damage, and the younger, more likely to be penalized, with the degree of dehydration increased, abnormal liver function enzymes, and the trend rate of increase.Clinicians should pay attention to the diarrhea stool rotavirus antigen and cardiac enzymes, liver function testing, and provide timely and targeted treatment.