支气管哮喘急性发作期患者治疗前后对外周血嗜酸性粒细胞计数的影响及其意义

摘要

Objective To explore the effect of montelukast on amounts of eosinophils in peripheral blood before and after treatment in patients with acute exacerbation of bronchial asthma.Methods The analysis of correlations between The amounts of eosinophils in peripheral blood and the level of serum eotaxin was carried out,the amounts of eosinophils in peripheral blood were measured by peroxidase method in 30 patients with acute exacerbation of bronchial asthma (treatment group) and 20 healthy control (control group),the levels of serum Eotaxin were measured by ELISA in two groups of patients.Results The amounts of eosinophils in peripheral blood (0.98 ±:0.20) × 109/L and the levels of serum Eotaxin(322.520 ± 91.376pg/ml) of the patients with bronchial asthma were significantly higher than those of the after treatment and healthy controls before treatment(P＜ 0.05),The number of blood eosinophils (0.25 ±:0.11) × 109/L and the level of serum Eotxin(126.367 ±:48.536)pg/ml were compared with healthy controls and no significant difference found after 3 months of treatment(P＞ 0.05),It was also found that the Eotaxin levels of the acute asthma group were positively correlated to the amounts of eosinophils in peripheral blood (r=0.594,P ＜ 0.05).Conclusion It suggest the montelukast can reduce the amounts of eosinophils in peripheral blood in patients with bronchial asthma and can control eosinophils in inflammatory response.%目的 探讨孟鲁司特钠对支气管哮喘急性发作期的患者治疗前后外周血嗜酸性粒细胞(Eosinophil,EOS)水平的影响.方法 应用过氧化酶法测定30例支气管哮喘急性发作期患者(治疗组)和20例健康者(对照组)的外周血EOS数量,同时用ELISA测定两组患者血清中嗜酸性粒细胞趋化因子(Eotaxin)水平,分析两组间EOS数量和Eotaxin水平的相关性.结果 治疗组治疗前患者的外周血EOS数量(0.98±0.20)×109/L和治疗前血清Eotaxin水平(322.520±91.376) pg/ml明显高于治疗后及对照组(P＜0.05),治疗3月后外周血EOS数量(0.25±0.11)×109/L和血清Eotaxin 水平(126.367±48.536) pg/ml与对照组比较差异无显著性(P＞0.05),治疗组治疗前外周血EOS数量与治疗前血清Eotaxin水平呈正相关(r=0.594,P＜ 0.05).结论 孟鲁司特钠能降低支气管哮喘患者外周血EOS数量,从而控制EOS的炎症反应.