Objective To study and analyze the effect of clinical immunotherapy with Chinese and western medicine for oral lichen planus and its adverse reactions.Methods 110 patients with oral lichen planus were selected from our hospital as a control group and were treated with levamisole.And another 110 patients with oral lichen planus were selected as an observation group and treated with levamisole and Chinese medicine for immunotherapy.The 8 weeks short-term efficacy and 1 year long-term efficacy were observed in both groups.The levels of interleukin 6 and 8 and tumor necrosis factor alpha were observed before and after the treatment.Results The short-term efficacy was 94.5％ (104/110) in the observation group and 83.6％ (92/110) in the control group (x 2=3.87,P＜0.05).The long-term efficacy was 91.8％(101/110)in the observation group and 66.4％ (73/110) in the control group (x 2=7.24,P＜0.05).The levels of interleukin 6 and 8 and tumor necrosis factor alpha were (1.03±0.14),(12.09±2.04),and (12.46±2.10) in the observation group and were (2.29±1.04),(15.34±3.23),and (15.39±2.34) in the control group,with statistical differences (P＜0.05).After 8 weeks' treatment,13 cases got adverse reactions in the control group and none in the observation group,with a statistical difference.Conclusions Clinical immunotherapy with Chinese and western medicine for oral lichen planus is effective and can speed up the patients' recovery of oral mucosa.%目的 研究并分析运用中西医临床免疫治疗口腔扁平苔藓患者的临床效果以及不良反应.方法 在本院选取1 10例口腔平苔藓患者为对照组,给予西药左旋咪唑进行治疗;此外另选取110例口腔扁平苔藓患者为观察组,在对照组基础上再给予中药进行临床免疫治疗.观察两组治疗8周后近期疗效和1年后远期疗效,此外还要注意观察治疗前后白细胞介素6、8以及肿瘤坏死因子α水平.结果 近期疗效:观察组治疗总有效率为94.5％ (104/110),对照组治疗总有效率为83.6％(92/110),观察组明显高于对照组(x 2=3.87,P＜0.05);远期疗效:观察组治疗总有效率为91.8％ (101/110),对照组为66.4％(73/110),观察组明显高于对照组(x 2=7.24,P＜0.05);治疗后,观察组白细胞介素8、白细胞介素6、肿瘤坏死因子α水平分别为(1.03±0.14)、(12.09±2.04)、(12.46±2.10),对照组分别为(2.29±1.04)、(15.34±3.23)、(15.39±2.34),观察组明显优于对照组,差异有统计学意义(P＜0.05).对照组用药8周后共计13例患者出现不良反应状况,而观察组无不良反应发生,二者差异有统计学意义.结论 口腔扁平苔藓患者运用中西医临床免疫的方法进行治疗,其临床疗效较佳,可促进患者口腔黏膜恢复.
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