纳米钛膜种植体-骨界面的骨整合研究

摘要

目的 研究纳米材料在种植体骨整合方面的作用.方法 以磁控溅射法在纯钛种植体表面制备纳米钛膜,观测其形貌,将其植入动物体内,研究其在动物体内的早期骨整合情况.结果 表面形貌分析显示,磁控溅射在片状种植体和柱状种植体上形成的纳米级颗粒尺度相近,片状种植体纳米颗粒分布更均匀.动物试验显示,纳米级颗粒钛膜可增加种植体在种植初期的骨整合、骨小梁数量和骨量.结论 在材料表面行纳米粒度钛膜改性,有助于提高材料与骨之间的生物活性.%Objective The aim of this article is to study on the nano-scale materials in the role of implant os seointegration. Methods In this study, nano-scale titanium films were prepared by direct magnetron sputtering on titanium implants. Then the prepared implants coating with the nano-scale thin film are implanted in the bones of animals. The study of the early integration of the bone will be done between the experimented and control groups. Results Analyzed superficial configuration by magnetron sputtering, it showed that nano-scale granular diaphragm formed and it was homogeneous and compact. Dimension of nano-scale granular on lamellar implants was similar with that on columnar implants. However, nano-scale granular was more homogeneous in lamellar ones. The result of animal experiment showed that initial osseointegration increased after implant surgery utilized implants coating by nano-scale titanium thin film. Conclusion Serial animal experimentation manifested that bioactive can be improved after nano-scale titanium thin film formed on the surface of materials.