儿童复发性阿弗他溃疡病因学的研究进展

摘要

Recurrent aphthous ulcer (RAU) is the most common ulcerative disease of the oral mucosa. Although RAU appears in all ages, the onset of RAU peaks during childhood. Childhood RAU, as a special patient group, displays distinct etiology. The etiology of childhood RAU includes genetic, local trauma, psychologic, nutritional factors, microbial infection, and abnormal immunologic response. Moreover, some cases of childhood RAU are associated with several systemic diseases. This article presents the current progress on the etiology of RAU in children.%复发性阿弗他溃疡(RAU)是最常见的口腔黏膜溃疡类疾病,虽然在各个年龄段均可发病,但其首发多见于儿童期.RAU儿童作为该病患者中的特殊群体,在病因学上具有一定的特殊性.目前已知的与儿童RAU有关的病因包括遗传因素、局部创伤、心理因素、营养缺乏、微生物感染、免疫反应异常等,此外,一些儿童RAU还与多种全身系统疾病有关,本文针对儿童RAU病因学的研究进展作一综述.