儿童激素敏感、依赖和频复发性肾病综合征的治疗进展

摘要

原发性肾病综合征(primary nephrotic syndrome,PNS)是儿童常见的肾脏疾病,糖皮质激素(glucocorticosteroid,GC)是公认的一线用药,大部分患儿对其治疗敏感.然而,复发和激素依赖的问题一直未能得到解决.近年来就GC疗程,免疫抑制剂的疗效和安全性以及如何有效降低复发和激素依赖分别进行了多项的随机对照研究.该文就激素敏感、依赖和频复发性肾病综合征治疗方面的研究进展进行综述.%Primary nephrotic syndrome( PNS) is a common kidney disease in children. Glucocorticoste-roid( GC) is recognized as the first-line drug,and most children are sensitive to it. However,the problems of fre-quent relapses and steroid-dependence still have not been solved. In recent years,a number of randomized con-trolled studies have been conducted on the dosage of GC medications,the efficacy and safety of immunosuppres-sive agents,some of which try to figure out how to effectively reduce relapse and the rate of hormone-depend-ence. This review summarizes the progress in the treatment of steroid-sensitive,steroid-dependent,and frequently relapsing nephrotic syndrome.