糖皮质激素治疗儿童急性肺损伤/急性呼吸窘迫综合征的研究进展

摘要

Pediatric acute lung injury/acute respiratory distress syndrome (ALI/ARDS)refers to a special syndrome with high mortality, acute progressive respiratory failure with loss of epithelial and endothelial integrity induced by severe stress reaction and/or inflammation reaction because of pulmonary and/or extrapulmonary diseases.Corticosteroids are routinely used in patients with ALI/ARDS for many years. Corticosterioids play an important role in every link of the therapy of ALI/ARDS because of the effect of anti-fibrosis and anti-inflammation, but it is unclear why the effect of treatment is very different in individual. The use of corticosteroid in the treatment of ALI/ARDS has been subject of great controversy and debate over the years. Recent researches indicate that the effect of glucocoticoids treatment is related with the number and affinity of the receptor for glucocorticoids.%儿童急性肺损伤/急性呼吸窘迫综合征(ALI/ARDS)是许多肺内疾病和(或)肺外疾病所致的严重应激反应和(或)严重炎症反应而导致的肺组织内皮和上皮受损引起的急性呼吸衰竭,病死率很高.糖皮质激素是目前临床使用最为广泛的抗纤维化和抗炎症药物,但由于其疗效差异较大,故在治疗ALI/ARDS中一直存在争议.近年研究表明其作用与糖皮质激素受体数量及亲和力有密切关系.