环境内分泌干扰物和儿童性发育障碍

摘要

儿童性发育障碍是成因复杂、临床表现多样的一类疾病,近年来发病率逐渐上升,发病机制正被不断揭示.环境内分泌干扰物被认为可以干扰正常性别分化过程,导致性发育障碍的产生.该文主要综述环境内分泌干扰物干扰性别分化过程的机制,探讨环境内分泌干扰物和儿童性发育障碍发病之间的关系.%Disorder of sexual development(DSD) refers to a group of diseases with various causes and phenotypes.It has attracted great worldwide as the incidence is rising and the life-long consequences accompanying.Environmental endocrine disruptors(EED) are thought to have an impact of the sex differentiation process and induce disorder of sexual development.This review summarizes the mechanism of DSD that associated with EED and focus on the relationship between DSD and EED.