肺表面蛋白B、C与新生儿呼吸窘迫综合征相关性研究进展

摘要

新生儿呼吸窘迫综合征(neonatal respiratory distress syndrome,NRDS)是新生儿较常见的危重症之一,其发病与肺表面蛋白(surfactant protein,SP)基因变异有密切相关.SP是肺表面活性物质(pul-monary surfactant,PS)的重要组成部分,在肺表面活性物质的结构、代谢、功能方面起重要作用.SP-B和SP-C在PS中极为重要,有密切关联.研究其等位基因变异与NRDS的关系有助于早期基因干预,促进临床诊断和治疗,对降低新生儿病死率具有长远的意义.%Neonatal respiratory distress syndrome is one of the common critically ill newborn's disease, the pathogenesis of which is closely related to gene mutation of the pulmonary suffactant protein(SP).Surfactant protein is an important component of the pulmonary surfactant, which plays an important role in the structure, metabolism, and function of pulmonary surfactant.SP-B and SP-C in pulmonary surfactant is extremely important and closely related to each other.Study on relationship between the SP gene allelic variation and neonatal respiratory distress syndrome could contribute to early genetic intervention, promote the clinical diagnosis and treatment, and bring far-reaching significance to reduce the neonatal mortality rate.