Continuous positive pressure ventilation combined with pulmonary surfactant in the treatment of neonatal respiratory distress syndrome

摘要

Objective: To analyze the clinical effect of nasal continuous positive airway pressure (CPAP) combinedwith pulmonary surfactant in the treatment of neonatal respiratory distress syndrome (NRDS).Methods: Eighty-two NRDS patients who received treatment from August 2017 to June 2019 in our hospitalwere selected and divided into a control group and an observation group using random number table,41 in each group. The control group was treated with CPAP, and the observation group was treatedwith pulmonary surfactant injection besides CPAP. The therapeutic effect, blood gas index, mechanicalventilation parameters and occurrence of complications were compared between the two groups.Results: The total response rate of the observation group was 90.24%, which was significantly higher than70.73% of the control group, and the difference had statistical significance (P0.05). After treatment, theimprovement of blood gas indexes of the observation group was better than that of the control group. Thehospitalization time and duration of oxygen treatment of the observation group were shorter than those ofthe control group, and the hospitalization cost was higher than the control group (P0.05). The differenceof incidence of complications between the two groups was statistically significant (P0.05).Conclusion: Endotracheal injection of pulmonary surfactant combined with CPAP in the treatment ofNRDS can enhance the efficacy, promote the recovery of blood gas index, and reduce the parameters ofmechanical ventilation and the incidence of complications, which is conducive to improving the respiratoryfunction of the newborn. The therapy is worth application in the treatment of NRDS patients.