毛细支气管炎与间充质干细胞的相关性研究

摘要

毛细支气管炎是婴幼儿时期最常见的下呼吸道感染性疾病,其主要的病原体为呼吸道合胞病毒,且与哮喘的发生密切相关.关于毛细支气管炎的发病机制目前仍未完全阐明,也尚无特异性的治疗手段.近来研究发间充质干细胞在减轻气道炎症、气道高反应性及修复气道损伤等方面具有强大的优越性.该文就近年来对毛细支气管炎发病的免疫学机制与间充质干细胞的相关性研究作一综述.%Bronchiolitis is the most common lower respiratory infection disease in infants and children.The main pathogen of bronchiolitis is respiratory syncytial virus (RSV),which is closely related to the occurrence of asthma.By far,the pathogenesis of bronchiolitis has not yet been fully elucidated.There is also no specific treatment for bronchiolitis.Recent studies have found that mesenchymal stem cells has strong advantages in reducing airway inflammation,airway hyperresponsiveness and airway damage repair and other aspects.This review mainly summarizes the association between bronchiolitis immunological mechanisms and mesenchymal stem cells.