细菌溶解产物防治儿童反复呼吸道感染的临床疗效观察

摘要

Objective To observe the efficacy of bacterial lysate(bronchovaxom) in the acute phase of respiratory tract infection and to prevent recurrent respiratory tract infections.Methods From April 2014 to A-pril 2015,in pediatric respiratory ward of Shengjing hospital of China Medical University,80 children with recur-rent respiratory tract infection were randomly divided into treatment group and control group,with 40 cases in each group.The control group patients were received routine anti-infection and symptomatic treatment,the treat-ment group patients were received oral bacterial lysis products for 3 months on basis of the conventional anti-in-fection and symptomatic treatment.To observe the duration of clinical symptoms of two groups of children with respiratory tract infection in the acute phase,antibiotic use and hospital stay changes;observed the number of re-spiratory infections occurred again within 1 year;measured the levels of serum immunoglobulin before and 6 months after treatment. Results Compared with the control group,the duration of symptoms such as fever, cough and other symptoms of respiratory tract infection,the duration of pulmonary rales,the use of antibiotics and the length of hospital stay were significantly shortened in the treatment group,and the number of respiratory infections was significantly reduced,the difference significant(P<0.05).After treatment,the levels of IgG and IgA in the treatment group were significantly higher than those before treatment,and the immunoglobulin IgG and IgA in the treatment group were significantly higher than those in the control group(P<0.05).Conclusion Oral bacterial lysis products to prevent respiratory infections,not only can reduce the duration of various clini-cal symptoms of respiratory tract infection,shorten the use of antibiotics and hospital stay,and can improve chil-dren's immunity,reduce the number of respiratory infections again.%目的 本研究旨在观察细菌溶解产物(泛福舒)在呼吸道感染急性期及预防再发呼吸道感染的疗效.方法 选取2014年4月至2015年4月中国医科大学附属盛京医院小儿呼吸病房因反复呼吸道感染住院的80例患儿,随机分为治疗组及对照组各40例,对照组给予常规抗感染及对症治疗,治疗组在常规抗感染及对症治疗基础上加用口服泛福舒3个月,观察2组患儿在呼吸道感染急性期各临床症状持续时间、抗生素使用及住院时间变化;观察1年内再次发生呼吸道感染次数;测定两组治疗前及治疗后6个月血清免疫球蛋白指标.结果 与对照组比较,治疗组呼吸道感染急性期发热、咳嗽等症状持续时间、肺部啰音持续时间、抗生素使用及住院时间等均明显缩短,再次发生呼吸道感染次数明显减少,差异有统计学意义(P<0.05);治疗组治疗后血清免疫球蛋白IgG、IgA较治疗前明显升高,治疗组治疗后免疫球蛋白IgG、IgA较对照组治疗后免疫球蛋白IgG、IgA明显升高,差异有统计学意义(P<0.05).结论 口服泛福舒防治呼吸道感染,不仅可以减轻呼吸道感染急性期各种临床症状持续时间,缩短抗生素使用时间及住院时间,同时可以提高患儿免疫力,减少再次呼吸道感染次数.