肺炎支原体血清学抗体检测现状与研究进展

摘要

Mycoplasma pneumonia(MP) is a common cause of children community-acquired pneumonia,and can lead to a variety of extrapulmonary complications.Thus,a rapid,sensitive diagnostic method is particularly important for early diagnosis and treatment.As MP grows slowly,requires additional nutrient supply and easy to be contaminated by fungi and bacteria during the culture process,culture of MP might not be suitable for clinical detection.However,the PCR technique is more complicated and high requirement for operator to be implemented in primary hospitals.Therefore,the serum diagnosis has become the commonly used method in clinical diagnosis.This paper is to review the latest findings of different serological diagnostic methods,antigen component,and antibody type in different periods of infection of MP.%肺炎支原体(Mycoplasma pneumonia,Mp)是引起儿童社区获得性肺炎的常见病因,并可引起多种肺外并发症.因此快速、敏感的诊断方法对于Mp的早期诊断和治疗尤为重要.由于Mp生长缓慢、对营养和环境要求较高、培养过程受真菌和细菌影响较大,普通培养法不能满足临床快速诊断.PCR技术复杂,对操作人员的要求较高,不适合在基层医院推行实施;因此血清学诊断成为目前临床最常用诊断方法.该文就目前临床及科研中Mp不同血清学诊断方法、抗原成分以及不同感染时期抗体成分的检测的最新研究进展进行综述.