慢性鼻-鼻窦炎患者鼻腔微生物群的研究概况

摘要

Lots of researches have elucidated the relationship between bacteria and CRS (chronic rhinosinusitis,CRS).Here we review the bacteriology progress of the CRS in recent years,from the technique of culture depend to the culture independ.The new technique takes a huge shift to understand the microbiology interacting with humans,and it's effect on CRS seems more and more important.As the conception of microbiome and microbiome diversity were generated,someone insists that it can be treat as an organ,and own the function on digestive tract,genital tract,respiratory tract and dermal system et al.The sinonasal cavity,which is the beginning of respiratory tract,the relationship between microbiome and chronic rhinosinusitis has been confirmed preliminarily.%细菌与慢性鼻-鼻窦炎的关系已有大量的研究,从传统的培养方法到现代的分子生物学检测技术,人们对微生物的认识发生了巨大的转变,其与慢性鼻-鼻窦炎的关系也越来越受到重视.随着微生物群、微生物群多样性等概念的提出,有人认为体内的共生微生物几乎可以看做是人体的另一器官,其与消化道、生殖道、呼吸道以及皮肤等多种器官疾病的相关性也已得到了大量数据的支持.作为呼吸道起始段的鼻腔,其内的微生物群与慢性鼻-鼻窦炎等疾病的相关性也得到了初步的探索.本文对几十年关于鼻腔鼻窦的细菌学研究做一综述.