目的 进一步探讨甲状腺功能指标和摄锝率测定在131I治疗Graves'病后早发甲低中的临床价值.方法 66例Graves'病经131I治疗后早发临床甲低患者,在左甲状腺素钠片替代治疗前后进行甲状腺功能检查及20 min摄锝率测定.结果 替代治疗前暂时性甲低和永久性甲低FT3、FT4及摄99mTc率均低于健康对照组,TSH高于健康对照组,差异均有统计学意义(P<0.01),而暂时性甲低组与永久性甲低组差异无统计学意义(P>0.05);替代治疗后暂时性甲低组各项指标恢复正常,永久性甲低组FT3、FT4和摄99mTc率分别低于健康对照组和暂时性甲低组,TSH高于健康对照组和暂时性甲低组,差异有统计学意义(P<0.01).结论 甲状腺功能和摄锝率测定早期不能鉴别暂发性甲低和永久性甲低.短时间替代治疗后暂时性甲低可恢复正常,而永久性甲低不能恢复.%Objective To investigate the clinical value of thyroid function indices and 99mTc thy-roid uptake rate in the early hypothyroidism following 131I treatment of Graves' disease. Methods 66 patients with early hypothyroidism following 131I treatment of Graves' disease,were enrolled in the in-vestigation. The thyroid funtion indices(FT3 ,FT4 and TSH) and 20 rain 99mTc throid uptake rate were determined before and after levothyroxine sodium replacement treatment. Results FT3 ,FT4 and 99mTc throid uptake rate in hypothyroidism group were significanthy lower than those in healthy control group,and TSH was significanthy higher (P<0.01). However, the differences of above parameters weren't statistically significant group between transient hypothyroidism and developing hypothyroidism group(P>0. 05). After replacement theraphy,the thyroid function and 99 mTc throid uptake rate recov-ered in transient hypothyroidism group. FT3,FT4 and 99mTc throid uptake rate in developing hypothy-roidism group were significanthy lower than those in healthy control group and transient hypothyroid-ism group,and TSH kept significanthy higher(P<0.01). Conclusion It isn't capable of differentia-ting transient and developing hypothyroidism with thyroid homone in dices and 99mTc thyroid uptake rate in the early phase. After a short time replacement therapy, the thyroid function and 99mTc throid uptake rate recover in transient hypothyroidism subjects,but don't recover in developing hypothyroid-ism subjects.
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