血清Cys-C、β_2-MG、RBP在2型糖尿病肾病早期诊断中的价值

摘要

目的 探讨血清Cys-C、RBP、β~2-MG在2型糖尿病肾病早期诊断中的应用价值.方法 根据尿白蛋白排泄率UAER将90例2型糖尿病患者分为3组,即正常组、微量组、大量组,对90例观察组和30例健康对照组的血清同时进行了CysC、β~2-MG、RBP、BUN、Crea 5项目平行检测,并作对比分析.结果 微量组和大量组Cys-C、β~2-MG、RBP 3项目结果与健康对照组比较均有非常显著增高,正常组与健康对照组比较差异无统计学意义.大量组阳性率分别为100%、100%、96.1%;微量组阳性率Cys C(92.3%)＞β2-MG(84.6%)＞RBP(66.6%)＞Crea(46.1%)＞BUN(28.2%).结论 血清Cys-C、β~2-MG、RBP在2型糖尿病肾病早期诊断中有较高的阳性检出率,可作为糖尿病.肾病早期诊断指标,尤其以Cys-C为理想指标.%Objective To evaluate the Cys-C、β~2-MG、RBP as marker三of early diagnosis in patients with diabetic nephropathy Ⅱ(DN).Methods ninety patients with DN were divided into three groups according to urinary albumin excretion rate (UAER),that is normal,micro and mass group.Serum Cys-C、β~2-MG、RBP、BUN,Crea were detected and parallelly contrasted in the three groups and control group with thirty healthy people.Results compared with the control group,the serum Cys-C、β~2-MG、RBP of micro and mass group both significantly increased and the normal group had no significant difference.The positive rate of Cys-C、β~2-MG,RBP in mass group was respectively 100%、100%、96.1%;the positive rate in micro group as follows:Cys C (92.3%)＞B2-MG(84.6%)＞RBP(66.6%)＞Crea(46.1%)＞BUN(28.2%).Conclusion serum Cys-C、β~2-MG、RBP have high positive rates in patients with diabetic nephropathy Ⅱ(DN).They can be used as early diagnostic marker of diabetic nephropathy Ⅱespecially Cys-C.