恶性肿瘤特异性生长因子对恶性肿瘤的诊断价值

摘要

Objective To evaluate the diagnostic value of tumor specific growth factor(TSGF) in the diagnosis of malignant tumors and to explore the advantages of TSGF as compared with other tumor markers. Methods Contents of TSGF,AFP and CEA were determined in 89 cases of patients with malignant tumors and 56 cases of healthy controls. Relative evaluation indicators were statistically analyzed. Results The sensitivity of TSGF in the diagnosis of malignant tumors was 80. 9 ％ . The sensitivities of TSGF in the diagnosis of non-small cell lung cancer and colorectal cancer were both higher than those of CFA respectively. The sensitivity of TSGF in the diagnosis of hepatocellular carcinoma was better than that of AFP,and the sensitivity of the combined detection of TSGF and AFP was 91. 7 ％ . Conclusion TSGF can be a tumor marker with high sensitivity and specificity,and with a broad application range,having certain clinical value in the serological screening and early diagnosis of malignant turnors. Combined detection of TSGF and other tumor markers can efficiently reduce false negative results.%目的 评价恶性肿瘤特异性生长因子(TSGF)对恶性肿瘤的诊断价值,并探讨与其他肿瘤标志物相比较的优越性.方法 通过对56例健康人和89例恶性肿瘤患者血清TSGF水平的测定,以及部分恶性肿瘤甲胎蛋白(AFP)、癌胚抗原(CEA)水平的测定,用统计学方法统计出相应的评价指标.结果 TSGF对恶性肿瘤的敏感度80.9%;对非小细胞性肺癌和肠癌的敏感度优于CEA对这两种癌症的敏感度;TSGF对肝癌的敏感度优于AFP对肝癌的敏感度,且两者联合检测的阳性率为91.7%.结论 TSGF是1种敏感度较高、特异性较强且广谱的血清肿瘤标志物,在临床肿瘤血清学筛查以及恶性肿瘤的早期诊断中有一定的应用价值.与其他肿瘤标志物联合检测,能更好地减少漏检的发生.