铜绿假单胞菌临床分离情况及对常用抗生素的耐药性分析

摘要

Objective To investigate the isolation and drug resistance of pseudomonas aeruginsa. Methods Bacteria were identi fled by using Vitek 32 auto microbe system and susceptibility tests were performed by using K B method. Results Among the 3 066 strains of Gram negative bacilli, 871 strains were pseudomonas aeruginosa (28. 4％). The isolation rates of pseudomonas aeruginosa were 65.2％ in sputum,16.6％ in secretion and 13.2％ in urine. The sensitivity of pseudomouas aeruginsa to meropen em, imipenem, cefepime, ceftazidime, ciprofloxacin, and piperacillin/tazobactam were 78. 5 ％, 75.2 ％, 67. 3 ％, 63. 6 ％, 63.4 ％ and　56.0 ％ respectively, but the sensitivity to the other 7 antibiotics were less than 60 ％. Conclusion The isolation and drug-resistance rates of pseudomonas aeruginosa were high and Pseudomonas aeruginosa infection should be treated by using meropenem, imipenem and orhers sensitive antibiotics alone or combined, according to the results of susceptibility tests.%目的 了解兰州军区乌鲁木齐总医院铜绿假单胞菌的分离情况及耐药特点.方法 细菌鉴定用Vitek 32全自动微生物鉴定仪,药敏试验用纸片琼脂扩散法.结果 在分离出的3 066 株革兰阴性杆菌中,铜绿假单胞菌为871株(28.4%),在非发酵革兰阴性杆菌中其分离率排第1位.铜绿假单胞菌在各类标本中细菌分离结果分析显示,以呼吸道标本痰分离率最高(65.2% ),其次是分泌物(16.6%)、中段尿(13.2%).铜绿假单胞菌敏感率较高的前6位抗生素分别是美洛培南(78.5%)、亚胺培南(75.2%)、头孢吡肟(67.3%)、头孢他啶(63.6%)、环丙沙星(63.4%)、哌拉西林/他唑巴坦(56.0%),其他的多种抗生素敏感率下降至60%以下.结论 铜绿假单胞菌的分离率及耐药率高,治疗该菌感染应根据临床分离株耐药性检测结果选用亚胺培南、美洛培南等敏感药物或联合用药.