Objective Influence on immune function of patient with breast cancer by herceptin unite with chemotherapy. Methods 87 patients with breast cancer were divided into two groups,one is chemotherapy group,another is herceptin unite with chemotherapy group. The expression of the lymphocyte sub group of these groups and 30 healthy physical examination people were detected by flow cytometry. Results The values of the CD3,CD4 and the ratio of CD4 and CD8 of chemotherapy group and herceptin u-nite with chemotherapy group were lower than control group during preoperative period, but the values of the CD19 of these two groups were higher than control group, yet when the values of CD8 and NK cell of these two group were compared with control group,the distinction was not significant. 34 patients of breast cancer by herceptin unite with chemotherapy were relieved,8 patient' s developed. 23 patient's condition of breast cancer by herceptin unite with chemotherapy wre relieved,22 patient's developed. Conclusion The herceptin unite with chemotherapy could notable increase curative effect of anti-breast cancer, but it also result in lower cell immune function of patient.%目的 观察赫塞汀联合化疗对乳腺癌患者免疫功能的影响.方法 87例乳腺癌患者分两组,45例化疗组和42例赫塞汀联合化疗组,流式细胞术检测2组患者和30例健康体检者外周血淋巴细胞亚群的表达.结果 化疗组和赫塞汀联合化疗组患者的CD3,CD4,CD4/8比值均低于正常对照组(P<0.05),CD19值均高于正常对照组(P<0.05);然而CD8、NK细胞值与正常对照组比较无统计学意义(P>0.05);化疗组与赫塞汀联合化疗组的淋巴细胞亚群值比较均无统计学意义(P>0.05).赫塞汀联合化疗组病情缓解34例,进展8例.化疗组病情缓解23例,进展22例.结论 赫塞汀联合化疗可显著提高乳腺癌的抗癌疗效,但也会导致患者细胞免疫功能低下.
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