FORECASTING METHOD OF TOXICITY IN PATIENTS WITH BREAST CANCER AFTER CONDUCTING combination chemotherapy with anthracyclines and taxanes by conducting diagnostic studies

摘要

A method of predicting toxicity of patients with breast cancer following chemotherapy combinations of taxanes, and anthracyclines by carrying out diagnostic tests, characterized in that for the prediction of later pankteatoksichnosti (toxic lesions of the pancreas) further evaluate the presence and severity of abdominal pain syndrome, and the results of pancreatic ultrasonograph and the detection of the typical pain and ultrasound signs of acute interstitial changes predict development of late pankreatoksichnosti (toxic damage of the pancreas); for predicting late cardiotoxicity further by echocardiography determined KDOI (index end-diastolic volume, the ratio of end-diastolic volume to body surface area) and the coefficient Ve / Va (ratio trasmitralnogo blood flow in early Ve and late Va left ventricular filling phase) and with increasing index KDOI (end-diastolic volume index) of higher than normal and reducing Ve / Va ratio (ratio of blood flow velocity in trasmitralnogo early (Ve) and late (Va) filling phase lion third ventricle) below normal forecast late cardiotoxicity.