孕妇ABO血型抗A(B)抗体效价检测分析

摘要

目的 了解该地区孕妇ABO血型抗A(B)IgG抗体效价异常率,分析其在新生儿溶血病(HDN)中的意义.方法 采用微柱凝胶法对4 000例孕周20周以上、O型血孕妇(丈夫为非O型血)进行血清抗A(B)IgG抗体效价检测;对抗体效价大于1∶64者所分娩新生儿进行HDN试验检测,分析抗体效价与HDN发病率的关系.结果 4 000例孕妇中,血清抗A(B)IgG抗体效价大于1∶64者有432例,异常率为10.8%(432/4 000);295例血清抗A(B)IgG抗体效价大于1∶64者所分娩的新生儿中,HDN发病率为53.9%(159/295).结论 随着血清IgG抗A(B)效价增高,HDN发病率也增高;产前抗体效价检测是可用于判断HDN发病风险的筛查指标.%Objective To analyze the abnormal rate of ABO blood group anti-A(B) IgG antibody titer in gravida in this area and its relationship with hemolytic disease of the newborn(HDN). Methods Microcolumn gel method was performed for the detection of antibody titer in 4 000 cases of gravidas. Neonatus,delivered by gravida with antibody titer more than 1 : 64 , were detected with HDN tests. Relationship between antibody titer and the incidence rate of HDN was analyzed. Results The abnormal rate of antibody titer was 10. 8%(432/4 000). In neonatus,delivered by gravida with abnormal antibody titer,the incidence rate of HDN was 53. 9% (159/295). Conclusion The incidence rate of HND could increase with the increasing of the titer of anti-A(B) antibody in gravida. Detection of antibody titer before delivery might be an effective indicator for the screening of HDN.