糖化血红蛋白联合D-二聚体和纤维蛋白原在2型糖尿病微血管病变中的应用

摘要

目的 探讨糖化血红蛋白A1c(HbA1c)联合D-二聚体(DD)和纤维蛋白原(FIB)在2型糖尿病(T2DM)微血管病变诊断中的应用.方法 分别检测134例T2DM患者HbA1c、DD及FIB水平,并以60例健康对照人群作比较分析.结果 T2DM患者HbA1c、DD和FIB明显高于健康对照人群,两组比较有统计学差异(P＜0.05)；T2DM合并微血管病变组中血浆HbA1c、DD及FIB三者呈正相关关系(P＜0.05),且均明显高于无微血管病变组(P＜0.05).HbA1c单项检测T2DM合并微血管病变(或T2DM无微血管病变)的阳性率低于HbA1c联合DD(或FIB),HbA1c联合DD和FIB检测的阳性率高于两项联合检测,比较差异有统计学意义(P＜0.05).结论 HbA1c联合DD和FIB检测有助于T2DM合并微血管病变的早期诊断和治疗.%Objective To investigate the application of the joint detection of glycosylated hemoglobin A1c (HbA1c),D-dimer (DD) and fibrinogen(FIB) in diagnosis of microangiopathy in patients with type 2 diabetes mellitus(T2DM).Methods 134 patients with T2DM were subjected to detection of HbA1c,DD and FIB,the results were compared with those of 60 healthy people who served as control.Results HbA1c,DD and FIB of patients with T2DM were significantly higher than those of healthy people with statistical difference(P＜0.05).Plasma H bA1c,DD and FIB were positively correlated in the group of T2DM combined with microangiopathy(P＜0.05) and they were all markedly higher than those in group without microangiopathy(P＜0.05).The positive rate of T2DM with microangiopathy(or T2DM without microangiopathy) by single HbA1c detection was lower than those by HbA1c detection combined with DD(or FIB).The positive rate of joint detection of HbA1c,DD and FIB was higher than those of joint detection of two indicators,and the difference was statistical significant(P＜0.05).Conclusion The joint detection of HbA1c,DD and FIB contributes to the early diagnosis and treatment of T2DM combined with microangiopathy.