血小板参数、纤维蛋白原和D-二聚体在2型糖尿病微血管病变患者中的表达及意义

摘要

Objective To investigate the expression and significance of platelet parametersplatelet, mean platelet vol-ume, platelet distribution width, plateletcrit and fibrinogen and D-dimer in type 2 diabetic patients with microangiopa-thy. Methods From May 2010 to May 2011, in Aerospace 731 Hospital, 122 patients with type 2 of diabetic were as diabetic group (65 cases with microangiopathy were as group A, 57 cases without microangiopathy were as group B) and at the same time 110 healthy volunteers were as control group. The platelet parameters and fibrinogen and D-dimer were observed and compared. Results The platelet parameters and fibrinogen and D-dimer in diabetic groups were significantly higher than those of the control group, the differences were statistically significant (P<0.05). 2 sub-group diabetic group, the of platelet parameters and fibrinogen and D-dimer of group A were significantly higher than those of group B, the differences were statistically significant (P<0.05). Conclusion The detection of platelet parame-ters, fibrinogen and D-dimer is conducive to early detection of diabetic microvascular disease, and treat them in ad-vance.%目的：探讨血小板参数即血小板、平均血小板体积、血小板分布宽度、血小板压积、纤维蛋白原和D-二聚体检测在2型糖尿病微血管病变患者中的表达及意义。方法2010年5月~2011年5月，在中国航天科工集团七三一医院住院的122例糖尿病患者(糖尿病组，其中微血管病变65例为A组，无微血管病变57例为B组)和110例健康体检者(对照组)的血小板参数、纤维蛋白原和D-二聚体被测定并比较。结果糖尿病组患者血小板参数、纤维蛋白原和D-二聚体指标高于对照组，差异有统计学意义(P<0.05)。糖尿病组内A组血小板参数、纤维蛋白原和D-二聚体指标高于B组，差异有统计学意义(P<0.05)。结论检测血小板参数、纤维蛋白原和D-二聚体有利于早期发现糖尿病微血管病变，以便于及早治疗。